Find hotels in Otay Mesa, San Diego from CA $97

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Apr 17 - Apr 18
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Apr 18 - Apr 19
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Apr 18 - Apr 20
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Apr 25 - Apr 27

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Discover 4,624 Otay Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Quality Suites San Diego Otay Mesa
Outdoor pool

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (999)
"location was ok. location is close to cbx"
The price is CA $140
CA $160 total
includes taxes & fees
May 4 - May 5
Quality Suites San Diego Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Exterior

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
7.6 out of 10, Good, (1411)
"Clean property, tucked away, no nearby shops or restaurants. "
The price is CA $183
CA $206 total
includes taxes & fees
Apr 27 - Apr 28
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Ayres Hotel San Diego South - Chula Vista
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1108)
"Wonderful stay! Omelette station! Large room with sofa! Easy parking! Right off interstate! Nice spa! Great stay! Keep up the good work. "
The price is CA $217
CA $240 total
includes taxes & fees
Apr 20 - Apr 21
Ayres Hotel San Diego South - Chula Vista
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Boating

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (975)
"Room clean bathroom clean but shower with some mold on the walls "
The price is CA $115
CA $130 total
includes taxes & fees
Apr 21 - Apr 22
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Best Western Chula Vista/Otay Valley Hotel
Lobby

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1382)
"Very close to CBX "
The price is CA $164
CA $180 total
includes taxes & fees
Apr 24 - Apr 25
Best Western Chula Vista/Otay Valley Hotel
Valli Hi Motel
Desk, blackout drapes, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very good, (1003)
"Good"
The price is CA $125
CA $140 total
includes taxes & fees
Apr 21 - Apr 22
Valli Hi Motel
Best Western Americana Inn
Pillowtop beds, in-room safe, desk, laptop workspace

Best Western Americana Inn

2.5 star property
8.8 out of 10, Excellent, (1069)
"Nice & quiet place to stay"
The price is CA $157
CA $177 total
includes taxes & fees
May 11 - May 12
Best Western Americana Inn
SpringHill Suites by Marriott Chula Vista Eastlake
Suite, 1 King Bed, Patio, Poolside | View from room

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (305)
"I really enjoyed my stay at SpringHill Suites. The property was clean, modern, and well-maintained — exactly what I was hoping for. The room was comfortable and stylish, with everything I needed for a relaxing stay. The location was another big plus — it’s conveniently situated near great restaurants, shops, and other local spots, making it easy to explore the area without needing to go far. Staff were friendly and efficient, and the overall atmosphere was calm and welcoming. I’d definitely...
The price is CA $243
CA $267 total
includes taxes & fees
Apr 21 - Apr 22
SpringHill Suites by Marriott Chula Vista Eastlake
Chula Vista Inn
Exterior

Chula Vista Inn

2.5 star property
6.6 out of 10, (1002)
"I’ve been coming to this hotel for on and off for two weeks never asked for a deposit then all of a sudden they want a deposit verify disappointed if that’s there policy they should have been charging me for a deposit from my first stay at this hotel."
The price is CA $116
CA $127 total
includes taxes & fees
Apr 20 - Apr 21
Chula Vista Inn
Quality Inn San Diego South - Chula Vista
Coffee service

Quality Inn San Diego South - Chula Vista

2.5 star property
7.6 out of 10, Good, (913)
"Parking is bit chellanging"
The price is CA $110
CA $121 total
includes taxes & fees
Apr 28 - Apr 29
Quality Inn San Diego South - Chula Vista
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1145)
"It was fine for what I needed, which was a place that was close to my son, but the maids carts rolling back-and-forth in front of the window throughout the evening was kind of noisy- room was clean "
The price is CA $140
CA $154 total
includes taxes & fees
Apr 27 - Apr 28
La Quinta Inn by Wyndham San Diego Chula Vista
Hercor Hotel - Urban Boutique
Daily continental breakfast (USD 13.49 per person)

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1151)
"Clean and great place to stay. Highly recommended. "
The price is CA $149
CA $164 total
includes taxes & fees
May 1 - May 2
Hercor Hotel - Urban Boutique
Days Inn by Wyndham Chula Vista/San Diego
Lobby

Days Inn by Wyndham Chula Vista/San Diego

2.0 star property
6.2 out of 10, (907)
"Nice clean property access to restaurants, freeway and gas stations"
The price is CA $133
CA $147 total
includes taxes & fees
May 7 - May 8
Days Inn by Wyndham Chula Vista/San Diego
Hotel Palmeras Chula Vista
Standard Room, 2 Queen Beds, Non Smoking

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1717)
"The room was spacious. There were some rusty spot around the refrigerator and in the bath tub. WiFi coverage was very weak in room 241, we had to use cellular data. "
The price is CA $97
CA $107 total
includes taxes & fees
Apr 27 - Apr 28
Hotel Palmeras Chula Vista
SureStay Hotel by Best Western Chula Vista San Diego Bay
Outdoor pool

SureStay Hotel by Best Western Chula Vista San Diego Bay

3.0 star property
7.8 out of 10, Good, (1376)
"Very clean room and great continental breakfast"
The price is CA $118
CA $131 total
includes taxes & fees
Apr 24 - Apr 25
SureStay Hotel by Best Western Chula Vista San Diego Bay
The Rambler Motel
View from room

The Rambler Motel

3.0 star property
9.0 out of 10, Wonderful, (1857)
"We loved the "chill" vibes! Very clean with comfortable beds and quiet rooms. They even provided us with cruiser bikes to ride on the trails which are close by. Thank you Rambler staff for the great hospitality! "
The price is CA $137
CA $158 total
includes taxes & fees
Apr 20 - Apr 21
The Rambler Motel
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed)

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3108)
"The staff was the best. We also like the eatery."
The price is CA $195
CA $215 total
includes taxes & fees
Apr 20 - Apr 21
Best Western Plus Marina Gateway Hotel
Loews Coronado Bay Resort
Exterior

Loews Coronado Bay Resort

4.0 star property
8.8 out of 10, Excellent, (1010)
"What a beautiful hotel!!! The view is incredible, the hotel is gorgeous, and the staff is top notch! Restaurant and cafe are wonderful as well. We’ll definitely be back! "
The price is CA $298
CA $394 total
includes taxes & fees
Apr 20 - Apr 21
Loews Coronado Bay Resort
Howard Johnson by Wyndham National City/San Diego South
Blackout drapes, iron/ironing board, free cribs/infant beds, free WiFi

Howard Johnson by Wyndham National City/San Diego South

2.0 star property
7.2 out of 10, Good, (1004)
"The hotel was easy to access from the freeway. We arrived around 11pm. The night clerk was not friendly and he seem to be bother to have to check me in. I called ahead to let him know i was running late. Breakfast could be better. They only had a continental breakfast. The coffee was good but there was no creamer/ half and half. They only had regular milk.the cleaning crew was great. They were super helpful and friendly. They clean our roo. Without having to requested. Overall it was a good...
The price is CA $129
CA $142 total
includes taxes & fees
Apr 21 - Apr 22
Howard Johnson by Wyndham National City/San Diego South
Glorietta Bay Inn Coronado Island
Front of property - evening/night

Glorietta Bay Inn Coronado Island

3.5 star property
8.6 out of 10, Excellent, (1001)
"We stayed in 2 bedroom suite for 3 nights. Lovely suite and very large. Love everything about this hotel except the breakfast, simply horrible!!! But the location is the best 👌 "
The price is CA $293
CA $388 total
includes taxes & fees
Apr 20 - Apr 21
Glorietta Bay Inn Coronado Island
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find out more about Otay Mesa

Find out more about Otay Mesa

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

How many hotels will I be able to find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodations, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.