4 Stars Hotels in Otay Mesa, San Diego from CA $142
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Otay Mesa 4 Star Hotels
Top Otay Mesa 4 Star Hotels
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Otay Mesa.

Pendry San Diego
550 J Street, San Diego, CA
The price is CA $394 per night from Apr. 12 to Apr. 13
CA $394
CA $517 total
includes taxes & fees
Apr 12 - Apr 13
9.2/10 Wonderful! (1,006 reviews)
Still don't see what you're looking for?
See all properties in Otay Mesa.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Reviews in Otay Mesa
Recent Reviews in Otay Mesa

Loews Coronado Bay Resort
5/5 Excellent
"This property is beautiful with views of the bay and the ocean."
A verified traveller stayed at Loews Coronado Bay Resort
Posted 7 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Otay Mesa Hotels by Star Rating
Hotels in Otay Mesa Neighborhoods
Hotels near Popular Otay Mesa Attractions
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near San Ysidro Border Crossing
- Hotels near Balboa Park
- Hotels near Petco Park
- Hotels near Mission Beach
- Hotels near San Diego State University
- Hotels near Hotel Circle
- Hotels near Marine Corps Recruit Depot
- Hotels near Port of San Diego
- Hotels near Naval Base San Diego
- Hotels near Coronado Beach
- Hotels near USS Midway Museum
- Hotels near University of San Diego
- Hotels near Mission Beach Boardwalk
- Hotels near B Street Cruise Ship Terminal
- Hotels near Hotel del Coronado
- Hotels near Seaport Village
- Hotels near Naval Base Coronado
More Hotel Options in Otay Mesa
- Beach Hotel in Otay Mesa
- Business Hotels in Otay Mesa
- Casino Hotels in Otay Mesa
- Cheap Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Golf Hotels in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Breakfast in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Hotels with Wifi in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Luxury Hotels in Otay Mesa
- Shopping Hotels in Otay Mesa
- Spa Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
Explore more hotels
- Handlery Hotel
- Comfort Inn Sea World Area
- Hilton San Diego Mission Valley
- Sheraton San Diego Resort
- Sheraton Mission Valley San Diego Hotel
- The Little Italy Hotel Downtown San Diego
- The Dextro Hotel, BW Premier Collection
- Lafayette Hotel & Club
- Wyndham Garden San Diego Near SeaWorld
- Bahia Resort Hotel
- Bay Club Hotel & Marina
- Kings Inn San Diego
- Hard Rock Hotel San Diego
- DoubleTree by Hilton Hotel San Diego - Mission Valley
- Palihotel San Diego Gaslamp Quarter
- Manchester Grand Hyatt San Diego
- Embassy Suites by Hilton San Diego Bay Downtown
- The Guild Hotel, San Diego, A Tribute Portfolio Hotel by Marriott
- Alma San Diego Downtown, a Tribute Portfolio Hotel
- Omni San Diego Hotel
More ways to book
Expedia's Latest Trends
Hotels
Ocean Beach hotelsKoreatown hotelsUnion Square hotelsDowntown San Diego hotelsDowntown San Francisco hotelsPacific Beach hotelsMission Valley hotelsDowntown Palm Springs hotelsDowntown Los Angeles hotelsLittle Italy hotelsGaslamp Quarter hotelsFisherman's Wharf hotelsOld Town San Diego hotelsHollywood hotels
Packages
General