Find Florida Keys 5 Star Hotels & Resorts from CA $388/night

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Check availability on Florida Keys 5 Star Hotels

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Top Florida Keys 5 Star Hotels

Cheeca Lodge & Spa

5.0 star property
9.0 out of 10, Wonderful, (1114)
"Wonderful stay - beautiful grounds "
The price is CA $388
CA $533 total
includes taxes & fees
Apr 27 - Apr 28
Cheeca Lodge & Spa

Isla Bella Beach Resort & Spa

5.0 star property
9.0 out of 10, Wonderful, (1125)
"Rooms and resort were very nice, staff was helpful and friendly, plenty of pools and very relaxing spa!"
The price is CA $468
CA $617 total
includes taxes & fees
Apr 27 - Apr 28
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Jogging trails, fishing spots, and popular sights from Everglades National Park to Duval Street—explore Florida Keys, a seaside destination also known for its live music scene.

Higgs Beach which includes a beach and tropical scenes as well as a large group of people

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
You can find several pricing options for a 5-star hotel in Florida Keys on Expedia. The amount you pay will depend on your travel dates, length of your trip and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to score the ideal upscale stay.

  • Search for the lowest price per night from CA $450

What makes a hotel 5 stars in Florida Keys?
From gourmet restaurants and 24-hour gyms to pools and deluxe bedding, the 5-star experience in Florida Keys is all about comfort and indulgence. But it calls for more than just top-notch perks to earn a 5-star rating. Stays must also provide outstanding guest-focused services like in-room massage treatments, on-site laundry and dry cleaning and 24/7 room service.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find an indulgent escape that includes your lodging, meals, drinks and entertainment in Florida Keys with Expedia’s filters. Search for hotels rated 5 stars and click on the “All inclusive” filter. Double-check what’s included in the upfront price. This way, you’ll be ready to maximize all the premium perks from the moment you arrive.
Are there any 5-star vacation rentals in Florida Keys?
Our site doesn’t offer any 5-star vacation rentals in Florida Keys. However, you will still find a few top-rated properties where the only item on your itinerary will be to unpack and have fun. See what’s available by searching through our vacation rentals in Florida Keys.