Find luxury hotels in Southeast Missouri, MO

  • Plan, book, stay with confidence

    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Check availability on Southeast Missouri Luxury Hotels

Tonight
Apr 28 - Apr 29
Tomorrow
Apr 29 - Apr 30
This weekend
May 2 - May 4
Next weekend
May 9 - May 11

Top Southeast Missouri Luxury Hotels

Super 8 by Wyndham Pevely
Desk, laptop workspace, blackout drapes, rollaway beds

Super 8 by Wyndham Pevely

2.0 star property
5.6 out of 10, (812)
"Arrived during tornado warning/ watch. Staff aware of danger. Very helpful"
Super 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO
Blackout drapes, free WiFi, bed sheets

Motel 6 Poplar Bluff, MO

2.0 star property
8.0 out of 10, Very good, (1007)
"Great value for the price "
The price is CA $110
CA $116 total
includes taxes & fees
Apr 29 - Apr 30
Motel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston
1 bedroom, desk, laptop workspace, blackout drapes

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1002)
"Nice and clean"
The price is CA $112
CA $128 total
includes taxes & fees
May 18 - May 19
Days Inn and Suites by Wyndham Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Property grounds

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

10.0 out of 10, Exceptional, (214)
"This upstairs unit is perfect for a long weekend getaway trip! It has everything you need and is in the perfect location to the downtown area. Walking distance to shopping and great restaurants! The area is very safe and my daughter and I are comfortable walking around the downtown area any time of day.Great owner with quick response time! We enjoyed our stay and will be back!!"
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Pear Tree Inn Cape Girardeau Near the Medical Center
Seasonal outdoor pool

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"Continental breakfast where the hostess made the waffles for you; friendly staff."
The price is CA $81
CA $91 total
includes taxes & fees
May 4 - May 5
Pear Tree Inn Cape Girardeau Near the Medical Center
Comfort Inn Festus - St Louis South
Lobby

Comfort Inn Festus - St Louis South

2.5 star property
8.0 out of 10, Very good, (808)
"I like the location of the hotel. It was clean and staff was friendly and helpful. "
The price is CA $125
CA $146 total
includes taxes & fees
May 4 - May 5
Comfort Inn Festus - St Louis South
Super 8 by Wyndham Poplar Bluff Missouri
In-room safe, desk, free WiFi, bed sheets

Super 8 by Wyndham Poplar Bluff Missouri

2.0 star property
6.6 out of 10, (550)
"Nice 👍🙂"
The price is CA $87
CA $99 total
includes taxes & fees
May 6 - May 7
Super 8 by Wyndham Poplar Bluff Missouri
Quality Inn Festus
Meeting facility

Quality Inn Festus

3.0 star property
6.8 out of 10, (895)
"Great place to stay "
Quality Inn Festus
Quality Inn
Lobby

Quality Inn

2.5 star property
7.0 out of 10, Good, (568)
"It was okay"
The price is CA $92
CA $104 total
includes taxes & fees
May 5 - May 6
Quality Inn
Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great staff. Called you by your name and were super helpful. The room was very spacious and comfortable. The whole property was clean and well maintained. The breakfast was very tasty and ample with a nice attendant making sure everything was available."
The price is CA $137
CA $158 total
includes taxes & fees
May 4 - May 5
Drury Inn & Suites Sikeston, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Southeast Missouri