Lake City Vacation Rentals from CA $172: Short-Term Rentals for 2025

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Vacation Rentals in Lake City

"Great location and well maintained home. "

CA $357 total

includes taxes & fees

Feb 12 - Feb 13

"We stayed in this home on our way home to Maryland from Florida. The home was perfect for our family. When we arrived the home was spotlessly clean and ready for us! We all got a great night sleep in this quiet and comfy home! Would definitely return!"

CA $386 total

includes taxes & fees

Mar 10 - Mar 11

"Our host David is wonderful and he accommodated us over the holidays with some short notice. The property is very clean and well kept. Check in and out was easy. There are plenty of towels and the kitchen has everything you’d need for a comfortable stay. I appreciated how easy it was to communicate with David during our stay. Thank you again!!"

"The accuracies of the reviews for this property are all on point. It is a beautifully remodeled bungalow in Historic Florence. The touches are all very elegantly and tastefully done. All the technology inside the house was easy to figure out, and it was very quiet and peaceful. The only negative feedback I would leave is that it would be really nice if the neighbors would put a bit more care into the appearance of their properties, and especially the neighbor across the street, who has...

"Great host and home. "

"Very nice home, clean and everything works. Bathroom door is awkward, but you get used to it. Older home so layout is not ideal, but it works. I would stay again. "

"Accommodated early arrival check in. Nice space and ample accommodations for four people. Easy to locate and access property."

CA $316 total

includes taxes & fees

Feb 15 - Feb 16

CA $401 total

includes taxes & fees

Feb 13 - Feb 14

CA $598 total

includes taxes & fees

Feb 12 - Feb 13

"This house was absolutely perfect! It was so clean and the views were amazing! We will definitely stay here again! "

CA $678 total

includes taxes & fees

Feb 10 - Feb 11

"Nice location and home. Owner was very responsive and accommodating. Matt promptly addressed our initial concerns after checkin. I would consider this home again for potential future bookings. "

"The property was very clean and had nice decor. Bed was very comfortable and liked that there was a lot of towels for us to use. Communication with the host was excellent. They responded right away to our questions prior to check in. Check in was a breeze. The kitchen had everything we needed. The note from the host was a nice surprise. Location was convenient in that it was close to restaurants and the hospital. Neighborhood was quiet."

"Great location and property."

"We went to Florence for a family reunion and wanted a place close by. The house is fine but slightly strange in its decor. It's perfectly fine, safe, and the host responds to questions very quickly,"

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Other types of properties in Lake City you may be interested in

"My husband and I booked an overnight away from the kids to celebrate our anniversary, and this was the perfect spot for that. We live close but had not been here before and we enjoyed the relaxing atmosphere and spacious room. The staff was so friendly and informative, and it was a much needed break from the chaos of everyday life. "

CA $231 total

includes taxes & fees

Feb 12 - Feb 13

"The updates and very quiet. "

CA $188 total

includes taxes & fees

Feb 23 - Feb 24

"Good "

CA $184 total

includes taxes & fees

Feb 10 - Feb 11

Find out more about Lake City

Everything you need to know about Lake City vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lake City vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lake City vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Lake City vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Lake City. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Lake City vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Lake City vacation rentals we have selected for you start as low as CA $172 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Lake City rentals

At Expedia, we put the best Lake City vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Lake City rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lake City vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lake City. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Lake City Vacation Rental Travel Info

Popular accommodation	Lake City agritourism lodgings
Known landmarks	The Country Club at Lake City and The Bean Market
International airports	Myrtle Beach, SC (MYR-Myrtle Beach Intl.) and Florence, SC (FLO-Florence Regional)

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Frequently asked questions

Can I find a vacation rental in Lake City?

Yes, we offer vacation rentals in Lake City near Moore Farms Botanical Garden, or you can choose a secluded option if you want a relaxing stay. Visitors to Lake City speak positively about the lakeside and restaurants in this destination. Make sure you have time to check out the shopping and parks during your trip.

What are some of the best vacation rentals that Lake City has to offer?

Walking distance from one of South Carolina's top Medical centers.: This vacation home rental outside of Lake City offers a garden, a selection of games, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What can I see and do in Lake City?

Lions Park and Moore Farms Botanical Garden are a couple of lovely local spots to get outside and enjoy nature. The Country Club at Lake City and Lynches Lake Historical Society are other places to visit while you're in town.

What are vacation rentals like in Lake City?

Vacation rentals are private properties you can stay in for a couple days or more in Lake City. Vacation rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a clean environment, vacation rentals can offer a sense of seclusion away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for family trips or small group gatherings.

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Lake City Vacation Rentals

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Check prices for these dates

Vacation Rentals in Lake City

Walking distance from one of South Carolina's top Medical centers.

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.

Hickory Haven 3Br Elegant Downtown Hidden Gem

Cheerful home with plenty of privacy and entertainment room.

Quaint Bungalow in Historic Downtown Florence

Oasis Located in the Heart of a Winery/ Halfway Point for Most Travelers

Simple & Sweet 2-bedroom house in amazing Florence

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Creekside Country Cottage- minutes away from I-95

Charming 3-bedroom house in Florence, SC

Great Home in the Greater Florence Area

Pineapple House: Historic. Southern Charm. Walk Downtown.

Family Retreat for vacations, weddings, family reunions and corporate retreats.

Luxury stay at 4 bedroom house

Camping it is!

Charming Farm House on 45 Acres

Charming 2 bedroom near downtown

Stylish 3B/2Ba Condo-Sleeps 6. Close to Florence Center, Shopping & Airport.

Work Friendly House Downtown Florence

Other types of properties in Lake City you may be interested in

The Inn at the Crossroads

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Find out more about Lake City

Lake City Vacation Rental Travel Info

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Frequently asked questions