Lake City Vacation Rentals from CA $180: Short-Term Rentals for 2025

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Vacation Rentals in Lake City

"Everything about this location was great and the host was very kind. Thank you for making our stay comfortable. "

"Nice place very clean "

CA $394 total

includes taxes & fees

Mar 18 - Mar 19

"Great host and home. "

"Nice location and home. Owner was very responsive and accommodating. Matt promptly addressed our initial concerns after checkin. I would consider this home again for potential future bookings. "

"Florence is the perfect half way point to meet with friends. The house was the perfect size , comfortable, and had everything we needed. I'm sure we will be back. "

CA $331 total

includes taxes & fees

Mar 23 - Mar 24

"Our host David is wonderful and he accommodated us over the holidays with some short notice. The property is very clean and well kept. Check in and out was easy. There are plenty of towels and the kitchen has everything you’d need for a comfortable stay. I appreciated how easy it was to communicate with David during our stay. Thank you again!!"

"The accuracies of the reviews for this property are all on point. It is a beautifully remodeled bungalow in Historic Florence. The touches are all very elegantly and tastefully done. All the technology inside the house was easy to figure out, and it was very quiet and peaceful. The only negative feedback I would leave is that it would be really nice if the neighbors would put a bit more care into the appearance of their properties, and especially the neighbor across the street, who has...

"Very clean, quite home. everything you need for an extended stay. "

"Accommodated early arrival check in. Nice space and ample accommodations for four people. Easy to locate and access property."

CA $315 total

includes taxes & fees

Mar 17 - Mar 18

"This is our second time at this property and we love it here! It is such an awesome place to getaway! The owner is so nice to work with too! We will definitely be back! "

CA $678 total

includes taxes & fees

Mar 12 - Mar 13

"The property was very clean and had nice decor. Bed was very comfortable and liked that there was a lot of towels for us to use. Communication with the host was excellent. They responded right away to our questions prior to check in. Check in was a breeze. The kitchen had everything we needed. The note from the host was a nice surprise. Location was convenient in that it was close to restaurants and the hospital. Neighborhood was quiet."

"We went to Florence for a family reunion and wanted a place close by. The house is fine but slightly strange in its decor. It's perfectly fine, safe, and the host responds to questions very quickly,"

"Great location and property."

"Everything was great,the rooms were clean there was a problem with knats and a there was a roach in the kitchen 😳 but overall the place was nice travis was kind i didn't really want to mention these,but i believe you can't fix a problem if you don't know about it again i really enjoyed my stay."

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Other types of properties in Lake City you may be interested in

"Very convenient area and friendly staff "

CA $224 total

includes taxes & fees

Mar 30 - Mar 31

"Stayed here only because all hotels in Florence SC, our intended destination were booked. Checked in after 11PM, didn't even enter in lobby, but passed my ID through to the employee on duty, who, in turn, passed me the keys. Room was clean, and provided a place to sleep for 7 hours before leaving to continue our trip"

CA $199 total

includes taxes & fees

Apr 8 - Apr 9

"Good "

CA $182 total

includes taxes & fees

Mar 18 - Mar 19

Find out more about Lake City

Everything you need to know about Lake City vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lake City vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lake City vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Lake City vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Lake City. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Lake City vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Lake City vacation rentals we have selected for you start as low as CA $180 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Lake City rentals

At Expedia, we put the best Lake City vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Lake City rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lake City vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lake City. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Lake City Vacation Rental Travel Info

Popular accommodation	Lake City agritourism lodgings
Known landmarks	The Country Club at Lake City and The Bean Market
International airports	Myrtle Beach, SC (MYR-Myrtle Beach Intl.) and Florence, SC (FLO-Florence Regional)

Recent reviews of Lake City properties

Quality Inn & Suites Florence Civic Center

5/5 Excellent

"Very good "

A verified traveller stayed at Quality Inn & Suites Florence Civic Center

Posted 1 day ago

5/5 Excellent

Overall great experience, minus one interaction

"I had a great stay both times I made an overnight stay (Feb 3, and then Mar 2, 2025. The beds are super comfortable, all I needed to break the road trip to Florida), however, there was much more to this. the rooms are clean and have everything you might need. Fringe, coffee maker, clean towels of complete sets, toiletries, individually controlled thermostat, working desk. I truly enjoyed my trip and didn’t think twice to book it sharing on my way back to DC from Florida. The only minor complaint I have is that the woman on shift on the March 2nd night ( going back to DC) at their Bistro was usually impolite to me, as if she didn’t want to talk to me or not inclined to take my order. There was some clear attitude, which is unusual in the service industry, specially hospitality. I don’t want to make it a race issue, but I couldn’t figure out why the attitude, since I didn’t even get to talk to her much, I felt she was avoiding and reluctant to respond to me. I didn’t find it worthwhile to call it out, just politely told her that I changed my mind and will eat dinner outside. I drove to nearby Sandwich shop, picked up dinner and came back to my room. On the contrary, when traveling to Florida (Feb 3rd) morning, the woman at breakfast shift went above and beyond and was polite. Otherwise, the hotel is great, the front desk staff was super friendly and helpful. There is a nice outdoor area to sit and let you dog run and sniff around. "

A verified traveller stayed at Courtyard by Marriott Florence

Posted 3 days ago

5/5 Excellent

"It’s been awhile since we stayed at a Comfort Inn. We just needed a quick stop for the night on our way home from vacation. Our room was clean and inviting, the bed was very comfortable, and the breakfast selection was more than adequate. We will definitely consider Comfort Inn for future trips. "

A verified traveller stayed at Comfort Inn & Suites

Posted 6 days ago

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Frequently asked questions

Can I find a vacation rental in Lake City?

Yes, we offer vacation rentals in Lake City near Moore Farms Botanical Garden, or you can choose a secluded option if you want a relaxing stay. Visitors to Lake City speak positively about the lakeside and restaurants in this destination. Make sure you have time to check out the shopping and parks during your trip.

What are some of the best vacation rentals that Lake City has to offer?

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees: This vacation home rental outside of Lake City is equipped with a patio, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What can I see and do in Lake City?

Lions Park and Moore Farms Botanical Garden are a couple of lovely local spots to get outside and enjoy nature. The Country Club at Lake City and Lynches Lake Historical Society are other places to visit while you're in town.

What are vacation rentals like in Lake City?

Vacation rentals are private properties you can stay in for a couple days or more in Lake City. Vacation rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a clean environment, vacation rentals can offer a sense of seclusion away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for family trips or small group gatherings.

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Lake City Vacation Rentals

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Check prices for these dates

Vacation Rentals in Lake City

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Cheerful home with plenty of privacy and entertainment room.

Cheerful home with plenty of privacy and entertainment room.

Elegant Historic Home w/ Modern Touch in Florence

Elegant Historic Home w/ Modern Touch in Florence

Great Home in the Greater Florence Area

Great Home in the Greater Florence Area

Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.

Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.

Hickory Haven 3Br Elegant Downtown Hidden Gem

Hickory Haven 3Br Elegant Downtown Hidden Gem

Quaint Bungalow in Historic Downtown Florence

Quaint Bungalow in Historic Downtown Florence

Oasis Located in the Heart of a Winery/ Halfway Point for Most Travelers

Oasis Located in the Heart of a Winery/ Halfway Point for Most Travelers

Creekside Country Cottage- minutes away from I-95

Creekside Country Cottage- minutes away from I-95

Pineapple House: Historic. Southern Charm. Walk Downtown.

Pineapple House: Historic. Southern Charm. Walk Downtown.

Luxury stay at 4 bedroom house

Luxury stay at 4 bedroom house

Family Retreat for vacations, weddings, family reunions and corporate retreats.

Family Retreat for vacations, weddings, family reunions and corporate retreats.

Charming 3-bedroom house in Florence, SC

Charming 3-bedroom house in Florence, SC

Cozy Work Friendly Condo in Florence

Cozy Work Friendly Condo in Florence

Camping it is!

Camping it is!

Charming 2 bedroom near downtown

Charming 2 bedroom near downtown

Charming Farm House on 45 Acres

Charming Farm House on 45 Acres

Stylish 3B/2Ba Condo-Sleeps 6. Close to Florence Center, Shopping & Airport.

Stylish 3B/2Ba Condo-Sleeps 6. Close to Florence Center, Shopping & Airport.

Other types of properties in Lake City you may be interested in

The Inn at the Crossroads

The Inn at the Crossroads

Quality Inn & Suites

Quality Inn & Suites

Days Inn by Wyndham Lake City

Days Inn by Wyndham Lake City

Find out more about Lake City

Find out more about Lake City

Lake City Vacation Rental Travel Info

Recent reviews of Lake City properties

Recent reviews of Lake City properties

Quality Inn & Suites Florence Civic Center

Explore a world of travel with Expedia

Explore a world of travel with Expedia

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Frequently asked questions