Taking into account the local weather in Guadalupe is an important factor for planning your visit, especially if you plan to spend your trip poolside. The hottest months are usually April and March with an average temp of 66°F, while the coldest months are January and February with an average of 65°F. The rainiest months in Guadalupe are October, June, August, and September, with each month seeing an average of 24 inches of rainfall.