Title: Book the Best BUSINESS Hotels in De Soto in 2026 | Expedia.ca

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![Kayaking down the Big River on a fall day! ](https://images.trvl-media.com/place/6085105/405982b2-f4d7-475b-927f-02fc53f853d1.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Jessica King

# Find Business Hotels in De Soto, MO from CA $83

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## Check availability on De Soto Business Hotels

Tonight

[Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-12-14&endDate=2025-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Tomorrow

[Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-12-15&endDate=2025-12-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Next weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

In two weeks

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

## Our top choices for De Soto business-friendly hotels

![Business centre](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/7e9b49ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/c41116cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/23ae42af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont Inn and Suites by Wyndham Farmington, MO

[](https://www.expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

Farmington

8.0/10

Very good

(1003)

"Room was clean , staff was friendly !"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sally

CA $74

CA $84 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/d234bb55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking, Refrigerator](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/d7244881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/5d1ea140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/3a2c35d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Farmington

[](https://www.expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Farmington.h855747.Hotel-Information)

Farmington

8.0/10

Very good

(612)

"Clean, friendly staff, quiet"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stacy

CA $73

CA $83 total

includes taxes & fees

Dec 20 - Dec 21

[](https://www.expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Farmington.h855747.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/1887aa70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/6e70629c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/a1c40704.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/e66aa4eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham Festus - St. Louis South

[](https://www.expedia.ca/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information)

Festus

8.0/10

Very good

(885)

"Staff was very nice ans helpful. Our room was clean and pleasant. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

ELLEN

CA $130

CA $149 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1100000/1095200/1095128/2dd0e783.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1100000/1095200/1095128/7df3af01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1100000/1095200/1095128/c9851c7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1100000/1095200/1095128/59299cdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Farmington by IHG

[](https://www.expedia.ca/Farmington-Hotels-Holiday-Inn-Express-Suites-Farmington.h1095128.Hotel-Information)

Farmington

8.6/10

Excellent

(412)

"The staff was great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christopher

CA $108

CA $341 total

includes taxes & fees

Jan 11 - Jan 12, 2026

[](https://www.expedia.ca/Farmington-Hotels-Holiday-Inn-Express-Suites-Farmington.h1095128.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/3ea7ebcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/70be7941.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/fc42ec39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/705e1bff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn Festus - St Louis South

[](https://www.expedia.ca/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information)

Festus

7.8/10

Good

(911)

"Vary clean"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

George

CA $104

CA $122 total

includes taxes & fees

Dec 16 - Dec 17

[](https://www.expedia.ca/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information)

![Premium bedding, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/20000/18500/18482/40607ed2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/20000/18500/18482/09284110.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/20000/18500/18482/496e3392.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/20000/18500/18482/77f907ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Farmington

[](https://www.expedia.ca/Farmington-Hotels-Quality-Inn-Farmington.h18482.Hotel-Information)

Farmington

7.6/10

Good

(861)

"The staff was friendly. We had a few issues with our stay but overall was good. Love there breakfast variety "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

edith

CA $70

CA $84 total

includes taxes & fees

Dec 28 - Dec 29

[](https://www.expedia.ca/Farmington-Hotels-Quality-Inn-Farmington.h18482.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/4000000/3870000/3861200/3861101/a7778b87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/4000000/3870000/3861200/3861101/876246e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/4000000/3870000/3861200/3861101/b11945d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/4000000/3870000/3861200/3861101/3ac9f95d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites St. Louis Arnold

[](https://www.expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Arnold.h3861101.Hotel-Information)

Arnold

9.6/10

Exceptional

(1001)

"Clean room, comfortable bed, free breakfast, dinner and drinks every night! We had a great stay, will definitely stay again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jacqueline

CA $169

CA $196 total

includes taxes & fees

Dec 18 - Dec 19

[](https://www.expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Arnold.h3861101.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/83119f36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/c44a2fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Jetted Tub, Golf View](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/a152ae07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/83886d8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Crown Pointe Lodge, BW Signature Collection

[](https://www.expedia.ca/Farmington-Hotels-Crown-Pointe-Lodge.h1429479.Hotel-Information)

Farmington

9.0/10

Wonderful

(574)

"Clean, friendly staff enjoyed the stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

CA $160

CA $182 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Farmington-Hotels-Crown-Pointe-Lodge.h1429479.Hotel-Information)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/219ce8d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, pillowtop beds, desk](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/6e9d01e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/e3f5b676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/540bf915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont by Wyndham Festus

[](https://www.expedia.ca/Festus-Hotels-Baymont-By-Wyndham-Festus.h5523.Hotel-Information)

Festus

6.8/10

(921)

"Room was clean and comfortable for an overnight stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jack

CA $112

CA $128 total

includes taxes & fees

Dec 16 - Dec 17

[](https://www.expedia.ca/Festus-Hotels-Baymont-By-Wyndham-Festus.h5523.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40112/d33a8d98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40200/40112/da3a948f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40112/ef39d78c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/40200/40112/d7498121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pear Tree Inn St. Louis Arnold

[](https://www.expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Arnold.h40112.Hotel-Information)

Arnold

9.4/10

Exceptional

(1002)

"The staff was very friendly and the rooms were very nice and clean"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Connie

CA $124

CA $143 total

includes taxes & fees

Dec 18 - Dec 19

[](https://www.expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Arnold.h40112.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-28&endDate=2025-12-29&regionId=6085105&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true)

## Top De Soto Hotel Reviews

![Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG](https://images.trvl-media.com/lodging/3000000/2700000/2699400/2699317/720261dc_y.jpg)

### Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

10/10 Excellent

"Clean, spotless, great room, front desk staff was excellent! Parking great!"

[](https://expedia.ca/Farmington-Hotels-Holiday-Inn-Express-Hotel-Suites-FESTUS-SOUTH-ST-LOUIS.h2699317.Hotel-Information)

![Super 8 by Wyndham Bonne Terre](https://images.trvl-media.com/lodging/1000000/860000/856300/856283/4bc8c9bd_y.jpg)

### Super 8 by Wyndham Bonne Terre

10/10 Excellent

"There great work nd staff"

[](https://expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Bonne-Terre.h856283.Hotel-Information)

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg)

### Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent

"The rooms where clean, the water was hot in the showers. The staff was family oriented and friendly felt like my family was safe."

[](https://expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Drury Inn & Suites St. Louis Arnold](https://images.trvl-media.com/lodging/4000000/3870000/3861200/3861101/a7778b87_y.jpg)

### Drury Inn & Suites St. Louis Arnold

10/10 Excellent

"The extra touches were a bonus "

[](https://expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Arnold.h3861101.Hotel-Information)

![Crown Pointe Lodge, BW Signature Collection](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/83119f36_y.jpg)

### Crown Pointe Lodge, BW Signature Collection

10/10 Excellent

"Clean, friendly staff enjoyed the stay"

[](https://expedia.ca/Farmington-Hotels-Crown-Pointe-Lodge.h1429479.Hotel-Information)

![Comfort Inn Festus - St Louis South](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/3ea7ebcc_y.jpg)

### Comfort Inn Festus - St Louis South

10/10 Excellent

"Vary clean"

[](https://expedia.ca/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information)

![Pear Tree Inn St. Louis Arnold](https://images.trvl-media.com/lodging/1000000/50000/40200/40112/d33a8d98_y.jpg)

### Pear Tree Inn St. Louis Arnold

10/10 Excellent

"Very nice overall. Beds were comfy, AC worked well, good water pressure for showers. If I am being nit-picky… the waffle syrup had no maple flavor at all. I don’t expect 100% Canadian maple syrup, but the syrup just tasted like corn syrup."

[](https://expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Arnold.h40112.Hotel-Information)

![Hampton Inn Farmington](https://images.trvl-media.com/lodging/4000000/3600000/3594600/3594547/3eea0c0d_y.jpg)

### Hampton Inn Farmington

10/10 Excellent

"Staff was amazing, super clean"

[](https://expedia.ca/Farmington-Hotels-Hampton-Inn-Farmington.h3594547.Hotel-Information)

![Quality Inn Farmington](https://images.trvl-media.com/lodging/1000000/20000/18500/18482/40607ed2_y.jpg)

### Quality Inn Farmington

10/10 Excellent

"Super easy check in"

[](https://expedia.ca/Farmington-Hotels-Quality-Inn-Farmington.h18482.Hotel-Information)

## Frequently asked questions

### How much do business-friendly hotels in De Soto cost?

### What are the best business-friendly hotels in De Soto?

### How many business-friendly hotels are there in De Soto?

### Are there any family-friendly hotels in De Soto that are also business friendly?

### Why book your business-friendly hotel in De Soto with Expedia?

### How can I find cheap business-friendly hotels in De Soto?

### What is there to do in De Soto near my business-friendly hotel?

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