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Compare 91 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (376)
"Staff were very friendly. Room was spacious and well designed."
The price is CA $99
CA $110 total
includes taxes & fees
May 9 - May 10
Quality Inn Charleston - Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (548)
"The carpet in the room needs to be vacuumed."
The price is CA $92
CA $102 total
includes taxes & fees
Apr 20 - Apr 21
Super 8 by Wyndham Charleston/Sikeston East MO

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (96)
"Middle of nowhere hotel was ok"
The price is CA $89
CA $99 total
includes taxes & fees
Apr 17 - Apr 18
Eagle Inn Charleston

La Center Motel

2.0 star property
7.6 out of 10, Good, (13)
"Clean, friendly, easy parking, good price, remodel restroom, good refrigerator and microwave "
The price is CA $91
CA $105 total
includes taxes & fees
Apr 17 - Apr 18
La Center Motel

Regency Inn

2.0 star property
The price is CA $132
CA $147 total
includes taxes & fees
May 7 - May 8
Regency Inn

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (250)
"We had a quiet and convenient one night stay. "
The price is CA $111
CA $123 total
includes taxes & fees
May 12 - May 13
Quality Inn Cairo I-57

The Riverview

3.5 star property
9.2 out of 10, Wonderful, (226)
"I enjoyed the Casino Access, Nice clean large rooms. Peaceful atmosphere. "
The price is CA $122
CA $137 total
includes taxes & fees
Apr 17 - Apr 18
The Riverview

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (408)
"Amazing "
The price is CA $187
CA $212 total
includes taxes & fees
Apr 27 - Apr 28
Courtyard by Marriott Cape Girardeau Downtown

Country Yard Inn and Suite

2.0 star property
7.0 out of 10, Good, (86)
"Good but WiFi weak "
The price is CA $89
CA $106 total
includes taxes & fees
May 6 - May 7
Country Yard Inn and Suite

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1001)
"Very accommodating staff"
The price is CA $112
CA $128 total
includes taxes & fees
May 6 - May 7
Days Inn and Suites by Wyndham Sikeston

Best Western Plus Sikeston

2.5 star property
8.4 out of 10, Very good, (1002)
"The gentleman at the front desk was super nice , friendly and just fun when we checked in , we had a quick overnight stay in town ! Pool was clean nice and warm , the next morning breakfast was nice clean and stocked and the young lady cleaning and keeping it full was very friendly also , plus we were able to have are Yorkie in room at a reasonable charge "
The price is CA $126
CA $143 total
includes taxes & fees
Apr 22 - Apr 23
Best Western Plus Sikeston

Rockwood Inn

2.0 star property
9.8 out of 10, Exceptional, (6)
"Had a wonderful stay at the Rockwood Inn and ready booked additional stay. Perfect location to stay at for football games or any other SEMO event! "
The price is CA $209
CA $236 total
includes taxes & fees
Apr 23 - Apr 24
Rockwood Inn

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Wonder stay! Excellent hotel. "
The price is CA $138
CA $159 total
includes taxes & fees
Apr 20 - Apr 21
Drury Inn & Suites Sikeston, MO

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
8.4 out of 10, Very good, (646)
"Inside hallways. Sink had a leak."
The price is CA $105
CA $120 total
includes taxes & fees
Apr 20 - Apr 21
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Comfort Inn & Suites Sikeston I-55

2.5 star property
8.4 out of 10, Very good, (249)
"It was okay, quiet and helpful."
The price is CA $129
CA $147 total
includes taxes & fees
May 4 - May 5
Comfort Inn & Suites Sikeston I-55

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1003)
"Nice room and comfortable bed. Only complain my would be the shower head. Needed a good clean. Water pressure was also low. "
The price is CA $119
CA $137 total
includes taxes & fees
Apr 20 - Apr 21
Pear Tree Inn Sikeston

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
6.6 out of 10, (523)
"Amazing "
The price is CA $96
CA $110 total
includes taxes & fees
Apr 20 - Apr 21
Super 8 by Wyndham Sikeston/Miner Area

Town House Inn Cape Giradreau

2.5 star property
6.0 out of 10, (178)
"NA"
The price is CA $84
CA $98 total
includes taxes & fees
Apr 17 - Apr 18
Town House Inn Cape Giradreau

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very good, (766)
"Wife and i stayed there for the zz top concert room was spacious very clean staff was super friendly. Had a little trouble figuring out the tv its a newer setup than we're used to. The bed was fwlt like it was a bit worn out still comfortable though but overall it was really great. "
The price is CA $114
CA $137 total
includes taxes & fees
Apr 27 - Apr 28
Candlewood Suites Cape Girardeau by IHG

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (100)
"Good"
The price is CA $130
CA $146 total
includes taxes & fees
May 4 - May 5
Fairfield Inn & Suites by Marriott Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Charleston

Quaint Charleston is calling! Discover its opera, entertainment, churches, and more.

Find out more about Charleston

Find out more about Charleston

Charleston Travel Info

Number of hotels
91
Highest price
CA $209
Lowest price
CA $84
Hotels with pet friendly rooms
3
Hotels with family-friendly amenities
2

Frequently asked questions

Where is the best place for a stay in Charleston?

Quality Inn Charleston - Sikeston is a favorite with Expedia customers. This hotel offers free breakfast and free parking. Another favorite option for your stay based on traveler reviews is Super 8 by Wyndham Charleston/Sikeston East MO. See all available top hotels, or vacation rentals in Charleston.

What's the top vacation rental that Charleston has to offer?

Serenity South -- Gardens, River-Views, and Refreshing Space: Visitors like this Charleston vacation home rental. It is located on a river and has a fireplace, a balcony, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. See all vacation rentals in Charleston.

If I need to cancel my hotel reservation in Charleston, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable if cancelled before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Charleston.

Where can I learn more about changing or cancelling my trip to Charleston?

To find more details about changing or cancelling your trip to Charleston, click here.

What's the best accommodation for a budget-friendly stay in Charleston?

Based on reviews, Quality Inn Charleston I-57 is a popular hotel for our travelers who want a more economical choice, and features free buffet breakfast and free WiFi. Another top option for your budget-friendly stay is Eagle Inn Charleston. View all budget hotels in Charleston.

What's the best pet-friendly hotel in Charleston?

Quality Inn Charleston - Sikeston is a top hotel for people traveling with their pets, and offers free WiFi for its human guests. Two other good options for you and your pet's trip include Super 8 by Wyndham Charleston/Sikeston East MO and Eagle Inn Charleston. See more pet-friendly hotel accommodations in Charleston.

What are some accommodations with pools in Charleston?

Best Western Plus Sikeston: Features free full breakfast, a pool, and free parking. Pear Tree Inn Sikeston and Drury Inn & Suites Sikeston, MO are a couple of other choices with an onsite pool. View all hotels with pools in Charleston.

What is the best spa hotel in Charleston?

Eagle Inn Charleston is a highly recommended spa hotel with a health club.

What's the best accommodation near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

How is it to stay in Charleston?

Visitors to Charleston are sure to enjoy the restaurants. Tourists can also enjoy the city's entertainment choices, theaters, and churches. In Charleston, there are 3 hotels and other accommodations to choose from. Find out more about Charleston.

What are the top places to visit in Charleston?

The picturesque setting of Mississippi River and Ohio River exemplify the area's natural beauty. You'll also find Columbus-Belmont State Park and The Book Bug in the area. Check out what more to see and do in Expedia's Charleston guide.

What's the seasonal weather like in Charleston?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Charleston is 59 inches.