Photo by Isa

Cayos Zapatilla Vacation Rentals

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Browse Select Cayos Zapatilla Vacation Homes

Surfari Bocas

2.5 star property
9.0 out of 10, Wonderful, (42)
"One of the best hostels I’ve ever stayed at. Affordable, clean, beautiful, welcoming hosts, and a very cute resident cat. Free coffee. Comfortable beds. Close to everything in Bocas Town. Hot water, although we had some trouble keeping the shower a constant temperature. However this really didn’t detract from our awesome stay!"
The price is CA $40
CA $44 total
includes taxes & fees
Nov 27 - Nov 28
Surfari Bocas

Private Villa at Red Frog Beach Resort

10.0 out of 10, Exceptional, (4)
"Red Frog Resort and our villa were beautiful. The villa was spacious with a nice kitchen and very clean. We enjoyed our stay. Renting a golf cart is very helpful because the resort is quite large."
Private Villa at Red Frog Beach Resort

Casa Clearwater... Your Caribbean Dream

10.0 out of 10, Exceptional, (5)
"One of our best trips ever, what a fabulous place to stay! Everything was perfect, great communication, easy to maneuver and get what you need!"
Casa Clearwater... Your Caribbean Dream

EcoHouse is surrounding nature & facing the breathtaking views of Caribbean Sea.

8.0 out of 10, Very good, (2)
"Upon arrival.. the property floors was covered in dust and debris. The sheets and pillows on the bed in the master bedroom was filthy and had a terrible smell of a man body odor. Master bathroom smell like old urine and the mirror had white spots on it. Both master bathroom rugs was dirty and had black debri on them. The light kept going on and off the entire evening and night, however Vigilio and his assistant was very prompt in taking care of this discrepancy. Virgilio and his team did a...
The price is CA $168
CA $458 total
includes taxes & fees
Nov 27 - Nov 28
EcoHouse is surrounding nature & facing the breathtaking views of Caribbean Sea.

Casa en la Jungla en Playa Bluff - Casa Bambú

Casa en la Jungla en Playa Bluff - Casa Bambú

Casa del Cielo

Casa del Cielo

Modern, Tranquil Beachfront House with Garden

Modern, Tranquil Beachfront House with Garden

Private Luxury Over the Water Bungalow

Private Luxury Over the Water Bungalow

Bocas Villas - Private Acqua Villas

9.0 out of 10, Wonderful, (34)
"Traumhaft ruhig!"
Bocas Villas - Private Acqua Villas

One Unique Island Escape in Bocas de Toro, Panama

10.0 out of 10, Exceptional, (12)
"Our stay at Urraca Private Island is the most awesome, memorable lodging experience we’ve had (and that’s saying a lot, because we travel frequently and have had many fantastic experiences). The place is amazing, kind of a cross between Swiss Family Robinson, Robinson Crusoe, and a high end Africa-style resort with adventure amenities like kayaks. And monkeys! This is the only place we know of that enables us to directly interact with sweet monkeys, even having one jump on our shoulders. The...
One Unique Island Escape in Bocas de Toro, Panama

Brand NEW Home Over on the Water

10.0 out of 10, Exceptional, (1)
"Lauren was a great host and was on point from pickup to departure. This is a pristine location for privacy and just minutes from town. The home was well kept and very clean! The waters in this area are beautiful and my girl friend and I took advantage of the paddle boards. We traveled to the other islands just 15 minutes away. I will stay here again for sure."
The price is CA $166
CA $198 total
includes taxes & fees
Nov 27 - Nov 28
Brand NEW Home Over on the Water

Casita del Mar, Bocas del Toro, Panama

10.0 out of 10, Exceptional, (53)
"Paradise on earth is that too much. The home was lovely, the amenities were great, the views were beautiful.the staff were so amiable, responsive, and professional. We hired the boat captain to take us to monkey island and zapatilla #2. It was a beautiful day. We hired the chef to cook for us for two nights, and we could not have enjoyed a better meal anywhere else. The food was amazing! We went into Bocas del Toro and it was a cute town but most of our time was spent at Casita Del Mar. You...
Casita del Mar, Bocas del Toro, Panama

Ocean Breeze - Bastimentos Island - Bocas del Toro

9.2 out of 10, Wonderful, (5)
"Old Bank is a community of contrasts. The Jamaican heritage was great, people generally friendly, and genuine. The downside was the massive piles of garbage strewn along the walkways and ocean. There were also warnings about safety and thieves on the beaches. Firefly restaurant is a must go for great food and service. It is more expensive, but worth it. Steve is a terrific communicator and obviously loves the people there. Basti is not comfortable for physically challenged, but if you want a...
The price is CA $180
CA $236 total
includes taxes & fees
Nov 27 - Nov 28
Ocean Breeze - Bastimentos Island - Bocas del Toro

Experience Paradise! This house was featured on HGTV House Hunters International

Experience Paradise! This house was featured on HGTV House Hunters International

Welcome to our beach front eco-friendly home in Bocas De Toro!

10.0 out of 10, Exceptional, (4)
"The house was great. Very quite and peaceful. Sambo is great. Def would stay again"
Welcome to our beach front eco-friendly home in Bocas De Toro!

Private Beachfront House with Kayak & Guided Tours

10.0 out of 10, Exceptional, (1)
"We had the absolute best time staying at this beach cabana. The bed was super cozy, the outdoor kitchen was awesome (make sure to bring all the food/beverages you need), the beach has the most beautiful clear water and loads of star fish and other fish and we were the ONLY people there and had the entire beach to ourselves, the locals were kind when passing and the host was extremely friendly and accommodating and had quick response to questions. We did a water taxi out there and had a pick up...
The price is CA $266
CA $266 total
includes taxes & fees
Dec 4 - Dec 5
Private Beachfront House with Kayak & Guided Tours

Perfect for Families, Surfers and Nature-Lovers!!

9.4 out of 10, Exceptional, (46)
"I thought the location was great. I love the sound of the ocean and the crashing waves right out front was amazing! Tyson was great with helping us find great people to take us on guides, kitchen was well equipped. The only things I think could have made it a little better would be better pillows, the mattress was really firm and I sleep on a firm mattress at home but these were very firm and the trees blocked a good portion of the view. Overall this is a great place to stay with lots to do...
Perfect for Families, Surfers and Nature-Lovers!!

STUNNING SPACIOUS 4 BDRM 2 BA BEACH HOUSE

4.0 out of 10, (2)
"We booked this 6 weeks in advance. Never heard from owner/manager. Finally got hold of someone 2 days before and they said sorry it was no longer available and they didn't have access to VRBO anymore."
STUNNING SPACIOUS 4 BDRM 2 BA BEACH HOUSE

Bocas Town Caribbean Style Over-the-Sea Home

10.0 out of 10, Exceptional, (2)
"The place was great! Very comfortable and beautiful view of water and sunsets. Highly recommend this rustic house over the water."
Bocas Town Caribbean Style Over-the-Sea Home

The Ultimate Beach House (Casa Sol Y La Luna)

9.8 out of 10, Exceptional, (20)
"Stay here. It’s stunning. Trip of a lifetime. Thank you Sunanda and Vincent for everything!"
The Ultimate Beach House (Casa Sol Y La Luna)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Cayos Zapatilla
Save an average of 15% on thousands of hotels when you're signed in

Other property types in Cayos Zapatilla

Surfari Bocas

2.5 star property
9.0 out of 10, Wonderful, (42)
"One of the best hostels I’ve ever stayed at. Affordable, clean, beautiful, welcoming hosts, and a very cute resident cat. Free coffee. Comfortable beds. Close to everything in Bocas Town. Hot water, although we had some trouble keeping the shower a constant temperature. However this really didn’t detract from our awesome stay!"
The price is CA $40
CA $44 total
includes taxes & fees
Nov 27 - Nov 28
Surfari Bocas

Eco-Lodge Bocas Coral Reef - Over water villa & birds house

9.0 out of 10, Wonderful, (9)
"The Eco Lodge was one of the highlights of our trip. Captain Eric was awesome and the property is beautiful. I’d highly recommend staying here. "
Eco-Lodge Bocas Coral Reef - Over water villa & birds house

Brand NEW Home Over on the Water

10.0 out of 10, Exceptional, (1)
"Lauren was a great host and was on point from pickup to departure. This is a pristine location for privacy and just minutes from town. The home was well kept and very clean! The waters in this area are beautiful and my girl friend and I took advantage of the paddle boards. We traveled to the other islands just 15 minutes away. I will stay here again for sure."
The price is CA $166
CA $198 total
includes taxes & fees
Nov 27 - Nov 28
Brand NEW Home Over on the Water
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until December 4 with our Black Friday deals. Stay by December 15, 2025.