Photo by Martina

Cayo Largo Vacation Rentals

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Vacation Rentals in Cayo Largo

Save an average of 15% on thousands of hotels when you're signed in

Other types of properties in Cayo Largo you may be interested in

Hotel Pelicano
3.5 star property
Hotel Pelicano
Bella Isla Resort
4.0 star property
6.0 out of 10, (7)
"- Zustand der Anlage: mittelmässig - Zustand und Sauberkeit unserer Villa: gut - Angebot an Essen/Getränken: sehr überschaubar - AI: einheimische Getränke kostenfrei - Fruchtsäfte müssen aber bezahlt werden - Erzeugnisse von CocaCola und ausländische Spirituosen müssen bezahlt werden - Qualität Essen: geniessbar, nichts besonderes zb. Ananas aus Dosen, keine Bananen (die wachsen aber überall an den Bäumen) - öfters tote Fliegen im Essen - während unseres Aufenthaltes z.B. keine Minze für Mojito...
Bella Isla Resort
Villa Iguana
3.0 star property
Villa Iguana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until December 4 with our Black Friday deals. Stay by December 15, 2025.

Frequently asked questions

Are there vacation rentals in Cayo Largo?

Yes, we give you a choice of vacation rentals close to the most popular points of interest in Cayo Largo, or you can select a secluded option if you'd like a relaxing place to stay. Cayo Largo is known for its beaches.

What’s there to see and do in Cayo Largo?

Cayo Largo del Sur and Playa Paraiso Beach are a couple of lovely local spots to get outside and enjoy nature. Other places in town to visit include Sirena Beach and Cayo Largo Marina.

What are vacation rentals like in Cayo Largo?

Vacation rentals are private accommodations you can reserve for a few days or a quick weekend in Cayo Largo. Vacation rentals offer amenities such as hot tubs, fire pits, and patios to help you enjoy your stay. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from shared hotel elevators and lobbies bustling with people while still allowing you to travel. You'll also find more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular choice for small groups.