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Top Cayo Guillermo Luxury Hotels

Beautiful view of the beach with palm trees

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Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Cayo Guillermo?
Amenities are important when you plan a vacation, so we make it easy to get what you’d like to make your stay special. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Cayo Guillermo has to offer. Cayo Guillermo has some interesting things to see and do including Cayo Guillermo Beach, so you might want to take in the local sights during your visit.
What's the best luxury place to stay in Cayo Guillermo?
Iberostar Daiquirí is a 4-star property with 3 restaurants and 4 bars, and it’s a popular choice for Expedia travelers looking for a pampering stay.
How many luxury hotels can I expect to find in Cayo Guillermo?
Lie in the lap of luxury during your getaway to Cayo Guillermo in one of Expedia’s 5 luxury hotels.
When can I expect good weather in Cayo Guillermo?
Planning for the weather is a good way to make your trip to Cayo Guillermo relaxing and enjoyable, especially when you’re splurging. The hottest months are usually August and September with an average temp of 83°F, while the coldest months are January and March with an average of 76°F. Average annual precipitation for Cayo Guillermo is 45 inches.
What's there to see and do in Cayo Guillermo?
Experience Cayo Guillermo with a stop at Cayo Guillermo Beach and Parque Natural el Bagá.