Photo by Skyy

Find Spa Hotels in Cape Girardeau, MO from CA $77

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Top Cape Girardeau Spa Hotels

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (674)
"It's a nice hotel to stay at, clean, convenient, and the staff are very friendly."
The price is CA $153
CA $173 total
includes taxes & fees
Dec 8 - Dec 9
Hampton Inn Cape Girardeau I 55 East

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Clean room. Great help at the front desk. Continental breakfast is a little lacking."
The price is CA $101
CA $114 total
includes taxes & fees
Nov 28 - Nov 29
Pear Tree Inn Cape Girardeau West

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (818)
"The property overall was really clean and updated. The surrounding area is full of restaurants and shops. I enjoyed my short stay"
The price is CA $120
CA $135 total
includes taxes & fees
Dec 21 - Dec 22
Drury Inn & Suites Cape Girardeau

Auburn Place Hotel And Suites

2.5 star property
8.8 out of 10, Excellent, (1009)
"I love going here when we visit! The pool is great during down time and the kids love playing the games. They have a good breakfast and are usually pretty friendly "
Auburn Place Hotel And Suites

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1002)
"What a wonderful hotel, great rooms, the bar and restaurant had really good food and drinks. The staff was very helpful and polite. Would stay there again and plan too."
The price is CA $138
CA $156 total
includes taxes & fees
Dec 8 - Dec 9
Drury Plaza Hotel Cape Girardeau Conference Center

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

2.5 star property
9.4 out of 10, Exceptional, (1006)
"It was great. "
The price is CA $132
CA $149 total
includes taxes & fees
Dec 8 - Dec 9
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

Candlewood Suites Cape Girardeau, an IHG Hotel

2.5 star property
8.2 out of 10, Very good, (698)
"Best place I have ever stayed"
The price is CA $124
CA $148 total
includes taxes & fees
Nov 25 - Nov 26
Candlewood Suites Cape Girardeau, an IHG Hotel

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Great place to stay. Plenty to see"
The price is CA $82
CA $92 total
includes taxes & fees
Dec 16 - Dec 17
Pear Tree Inn Cape Girardeau Near the Medical Center

Town House Inn Cape Giradreau

2.5 star property
6.0 out of 10, (156)
"It was a room to lay my head at night. Shower didn't work, ceiling paint was peeling and heavy smell of marijuana even though it was a no smoking room!"
The price is CA $77
CA $90 total
includes taxes & fees
Nov 24 - Nov 25
Town House Inn Cape Giradreau

3+ acre Home with New Hot Tub: Pool Table, Putt-Putt, 4 miles to Downtown

9.0 out of 10, Wonderful, (25)
"Amazing property that we simply didn't stay long enough to enjoy in its completeness. Billiards and Putt-Putt on entry, so attractive that we started playing before we even unpacked! I'm very artsy interior, and lots of room and outdoor fire pit, multiple decks, and an in-ground pool. The home is even on the grounds, an event venue. Probably a wonderful combination for them! Would enjoy returning, but for a longer stay will you could enjoy all with the property had to offer! Highly recommend it"
The price is CA $385
CA $542 total
includes taxes & fees
Dec 3 - Dec 4
3+ acre Home with New Hot Tub: Pool Table, Putt-Putt, 4 miles to Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Cape Girardeau
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until December 4 with our Black Friday deals. Stay by December 15, 2025.

Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia’s 58 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Isle Casino Cape Girardeau, Riverfront Bridge Park, and Show Me Center. If you have a bit of extra time while you’re in the area, you might want to check out Cape Splash Family Aquatic Center and Hunter Valley Winery.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.