Byron Vacation Rentals from CA $76: Short-Term Rentals for 2025

Q: What's the top vacation rental that Byron has to offer?

Century Cottage-PERFECT for Mayo & downtown visitors! : Visitors like this Byron vacation home rental. It is located in the city center and has a patio, a garden, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Make the most of the selection of games in this rental home to help you unwind.

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Vacation Rentals in Byron

"We have stayed at the Berkman several times and it's always been a wonderful experience!! The concierge service has always been so responsive and helpful, bringing us everything we need promptly! Our apartment is always very clean and comfortable. We always choose it when we are in Rochester!! "

CA $262 total

includes taxes & fees

Apr 17 - Apr 18

"My wife, daughter, and I had a great stay at the Century Cottage this past weekend. The house is very conveniently located between downtown Rochester and the Rochester Recreation Center. It was less than a mile walk/drive to the recreation center and a short drive to downtown Rochester. Mary was also very responsive to any messages we sent. All questions were answered within minutes. We would definitely stay here again if we're ever back in the Rochester area."

"Very good"

Microwave, dishwasher, coffee/tea maker, cookware/dishes/utensils

"Very clean property. It was comfortable and cute. The owners were responsive to us and so helpful"

"This is a wonderful house - great location, very clean, easy access to Mayo Clinic, shopping and restaurants. We will stay again. "

"Location was great easy to find and park. Nice short 10-15min walk to appts at Mayo building. House was very nice inside and very comfortable. "

"Enjoyed our stay, good communication."

"Very clear and easy check in process. Parking in definitely a pain if you need more than one spot. No parking on the two closest streets. Very easy walk to Mayo Clinic. Very cozy place with vintage furnishings. Only downfall was there was no ice melter in the place to put down. Everything was glare because of a storm. Toilet will keep running until you play with the handle for it to stop. Even with that I would still stay again. "

"Absolutely wonderfu"

"Nice location. Comfortable beds. Overall very accommodating "

"We came to town to visit a family member at Mayo. The home was just as the listing stated. The house is beautiful and has so much room…more than we could even use. There were lots of supplies for us and we had everything we needed for a comfortable stay. We only needed to contact host about adjusting the temperature and he quickly responded and gave us guidance on that. I would absolutely stay here again and suggest it to others as well. Five stars! "

Fridge, microwave, stovetop, coffee/tea maker

"We had the most lovely time talking and cooking and reconnecting with old friends. In fact we were so comfortable in this home we ordered in giving us more time to visit and play games. Thank you. Jennie"

1 bedroom, desk, iron/ironing board, free WiFi

"Room is very poorly lit. Not enough light sources, and they are dim."

CA $152 total

includes taxes & fees

Apr 7 - Apr 8

"I needed a place to stay while my husband had surgery at St. Mary’s. This was just perfect, little less than a mile walk away, felt perfectly safe. Apartment was beyond expectations, clean, cozy, all sorts of amenities. Thank you!"

CA $260 total

includes taxes & fees

Apr 2 - Apr 3

"Clinic visits can be stressful to say the least. Oasis Luxe Suite made our evenings relaxing. Wonderful stay."

"It would have been nice to get a heads up about mowing the lawn and having all the grass swept off of the sidewalk so we weren't walking through it and put it into the car or the house. TV remote was not in there The remote that was there did not go to that TV so we could not hook up our computer. The extras were nice. Surprisingly the two air conditioners kept the house cooled off. Not a bad place to stay would consider staying again."

"Very nice and clean. Close to Mayo Clinic which is why we were there. Would definitely recommend to others. Thank you!"

CA $310 total

includes taxes & fees

Apr 3 - Apr 4

"Needed a last minute place to stay with my elderly parents for Mayo appointments. The home was clean, cute, location great, easy to find--very homey."

CA $320 total

includes taxes & fees

Apr 10 - Apr 11

"Such a cute home. It was conveniently located near Mayo Clinic and St. Mary's Hospital. Loved the full size washer and dryer. Bedroom is downstairs and very quiet for restful sleep."

CA $277 total

includes taxes & fees

Apr 7 - Apr 8

"Convient, clean and accomidating."

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Other types of properties in Byron you may be interested in

"Pool clean but old hot tub wasnt working"

CA $126 total

includes taxes & fees

Apr 5 - Apr 6

"The two nights we stayed were some of the best sleep we have had in a long time! "

CA $267 total

includes taxes & fees

Apr 5 - Apr 6

"There is furniture sitting through the hallways. I only stayed one night and the power went out for around 2 hours overnight. Besides that everything was ok. The property is a bit out dated but that didn’t bother me. I just needed a clean place to sleep to go visit the Mayo clinic"

CA $206 total

includes taxes & fees

Apr 15 - Apr 16

Find out more about Byron

Everything you need to know about Byron vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Byron vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Byron vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Byron vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Byron. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Byron vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Byron vacation rentals we have selected for you start as low as CA $76 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Byron rentals

At Expedia, we put the best Byron vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Byron rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Byron vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Byron. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Recent reviews of Byron properties

5/5 Excellent

"The two nights we stayed were some of the best sleep we have had in a long time! "

A verified traveller stayed at Kahler Grand Hotel

Posted 16 hours ago

Kahler Inn and Suites - Mayo Clinic Area

5/5 Excellent

"There is furniture sitting through the hallways. I only stayed one night and the power went out for around 2 hours overnight. Besides that everything was ok. The property is a bit out dated but that didn’t bother me. I just needed a clean place to sleep to go visit the Mayo clinic"

A verified traveller stayed at Kahler Inn and Suites - Mayo Clinic Area

Posted 4 days ago

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Frequently asked questions

Can I find vacation rentals in Byron?

Yes, we offer vacation rentals in Byron close to Zollman Zoo, or you can go with a more remote option if you want a relaxing stay. Byron is known for its zoo and golf courses. Make sure you have time to check out the bars and parks during your trip.

What's the top vacation rental that Byron has to offer?

Century Cottage-PERFECT for Mayo & downtown visitors!: Visitors like this Byron vacation home rental. It is located in the city center and has a patio, a garden, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Make the most of the selection of games in this rental home to help you unwind.

What’s there to see and do in Byron?

Family-friendly attractions include Zollman Zoo, whereas Oxbow Park is a spot to enjoy the outdoors. While here, Links of Byron Mini Golf and Cheery Meadows Center are other places worth a visit.

What’s a vacation rental in Byron like?

A vacation rental is a private property you can stay in for a few weeks or just a few days in Byron. Vacation rentals offer amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about a sanitized environment, a vacation rental can offer a sense of safety away from public hotel elevators and busy reception areas while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a great option for a family getaway.

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Byron Vacation Rentals

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Vacation Rentals in Byron

The Berkman

The Berkman

Century Cottage-PERFECT for Mayo & downtown visitors!

Century Cottage-PERFECT for Mayo & downtown visitors!

Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham

Fresh space near Mayo Clinic and downtown

Fresh space near Mayo Clinic and downtown

Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.

Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.

Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.

Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.

"Walden Pond" Adventure Amidst 44 Private Acres

"Walden Pond" Adventure Amidst 44 Private Acres

Mayo Discount Available- 2Bedroom Close to Mayo

Mayo Discount Available- 2Bedroom Close to Mayo

Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

1 mi. from Mayo Clinic; Cozy, Clean

1 mi. from Mayo Clinic; Cozy, Clean

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

Luxury Stay/ Theater / Pool Table / Dogs Welcome

Luxury Stay/ Theater / Pool Table / Dogs Welcome

Coratel Inn & Suites by Jasper Rochester-2 Queen Bed Non Smoking

Coratel Inn & Suites by Jasper Rochester-2 Queen Bed Non Smoking

A Restful Retreat - Walk to Mayo - Free Parking

A Restful Retreat - Walk to Mayo - Free Parking

Oasis Luxe Suite—Steps from Mayo Clinic Hospital

Oasis Luxe Suite—Steps from Mayo Clinic Hospital

Mayo Discount Offered-Family-Friendly 2 Level-Near Mayo

Mayo Discount Offered-Family-Friendly 2 Level-Near Mayo

Discounted for Mayo Clinic Patients! 2 Bedroom Oasis 5 Minutes to Mayo Clinic!

Discounted for Mayo Clinic Patients! 2 Bedroom Oasis 5 Minutes to Mayo Clinic!

Discounted Charming 2-bedroom house in Rochester

Discounted Charming 2-bedroom house in Rochester

Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.

Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.

Upscale King Suite—Steps from Mayo Clinic Hospital

Upscale King Suite—Steps from Mayo Clinic Hospital

Other types of properties in Byron you may be interested in

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

Kahler Grand Hotel

Kahler Grand Hotel

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

Find out more about Byron

Find out more about Byron

Recent reviews of Byron properties

Recent reviews of Byron properties

Kahler Grand Hotel

Explore a world of travel with Expedia

Explore a world of travel with Expedia

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Frequently asked questions