4 Stars Hotels in Uptown, Collinsville from CA $126
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Uptown 4 Star Hotels
Top Uptown 4 Star Hotels

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
8.4 out of 10, Very good, (3631)
The price is CA $159
CA $188 total
includes taxes & fees
May 22 - May 23

Moonrise Hotel
Moonrise Hotel
9.0 out of 10, Wonderful, (1697)
The price is CA $217
CA $258 total
includes taxes & fees
May 26 - May 27

River City Casino & Hotel
River City Casino & Hotel
9.0 out of 10, Wonderful, (1178)
The price is CA $133
CA $175 total
includes taxes & fees
May 7 - May 8

21C Museum Hotel St Louis
21C Museum Hotel St Louis
9.2 out of 10, Wonderful, (1090)
The price is CA $223
CA $268 total
includes taxes & fees
May 22 - May 23

Live by Loews - St.Louis
Live by Loews - St.Louis
9.2 out of 10, Wonderful, (1002)
The price is CA $243
CA $289 total
includes taxes & fees
Apr 27 - Apr 28

Le Méridien St. Louis Clayton
Le Méridien St. Louis Clayton
8.8 out of 10, Excellent, (593)
The price is CA $211
CA $248 total
includes taxes & fees
May 4 - May 5

The Last Hotel
The Last Hotel
7.8 out of 10, Good, (1132)

Embassy Suites by Hilton St. Louis Downtown
Embassy Suites by Hilton St. Louis Downtown
8.6 out of 10, Excellent, (1126)
The price is CA $179
CA $213 total
includes taxes & fees
Apr 27 - Apr 28
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Uptown.

Four Seasons Hotel St Louis
999 North Second Street, St. Louis, MO
The price is CA $583 per night from Apr. 29 to Apr. 30
CA $583
CA $682 total
includes taxes & fees
Apr 29 - Apr 30
9.4/10 Exceptional! (998 reviews)
Still don't see what you're looking for?
See all properties in Uptown.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Reviews in Uptown
Recent Reviews in Uptown

Hyatt Regency St. Louis at The Arch
5/5 Excellent
"Staff was fantastic, especially Fredrick. "
A verified traveller stayed at Hyatt Regency St. Louis at The Arch
Posted 15 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Uptown Hotels by Star Rating
Hotels near Popular Uptown Attractions
- Hotels near World's Largest Catsup Bottle
- Hotels near Kruta Bakery
- Hotels near Enterprise Center
- Hotels near Busch Stadium
- Hotels near St. Louis Union Station
- Hotels near St. Louis Zoo
- Hotels near Gateway Arch
- Hotels near Washington University in St. Louis
- Hotels near Forest Park
- Hotels near Barnes Jewish Hospital
- Hotels near City Museum
- Hotels near Dome at America’s Center
- Hotels near St. Louis University
- Hotels near Mississippi River
- Hotels near Fox Theater
- Hotels near America's Center Convention Complex
- Hotels near Horseshoe St. Louis Casino
- Hotels near Anheuser-Busch Brewery
- Hotels near St. Louis Aquarium at Union Station
- Hotels near Missouri Botanical Gardens and Arboretum
Explore more hotels
- Hilton St. Louis at the Ballpark
- Casino Queen Hotel
- Embassy Suites by Hilton St. Louis Downtown
- Forest Park Hotel by MDR
- The West End
- Hampton Inn St. Louis-Downtown (At the Gateway Arch)
- Pear Tree Inn St. Louis Near Union Station
- Hilton Pennywell St. Louis at the Arch
- The Cheshire
- Marriott St. Louis Grand
- Holiday Inn St. Louis - Downtown Conv Ctr by IHG
- The Royal Sonesta Chase Park Plaza St. Louis
- St. Louis Union Station Hotel, Curio Collection by Hilton
- The Westin St. Louis
- Courtyard by Marriott St. Louis Downtown/Convention Center
- AC Hotel St. Louis Clayton
- Super 8 by Wyndham O'Fallon
- Pear Tree Inn St. Louis Convention Center
- Four Seasons Hotel St Louis
- Home2 Suites by Hilton St. Louis Downtown
Expedia's Latest Trends
Hotels
Fulton Market hotelsThe Loop hotelsHotels with Free Parking in Downtown ChicagoCheap Hotels in Downtown ChicagoMagnificent Mile hotelsRiver North hotelsMajestic Elegance Punta Cana - All InclusiveWicker Park hotelsGold Coast hotelsLincoln Park hotelsDowntown Chicago hotelsWest Loop hotelsHotels in OrilliaCheap Hotels in Toronto
Flights
Cheap Flights to New YorkFlights to MaldivesUnitedCheap Flights from Windsor (YQG) to Vancouver (YVR)Cheap Flights from Toronto (YYZ) to London (YXU)Flair AirlinesCheap Flights from Vancouver (YVR) to Terrace (YXT)Cheap Flights from Delhi (DEL) to Toronto (YYZ)Cheap Flights from Windsor (YQG) to Calgary (YYC)