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Isla Bella Beach Resort & Spa
Five Star Hotels in Florida Keys
There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Florida Keys so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Florida Keys and get ready to be pampered like never before.
Get a Great Deal on 5-Star Hotels in Florida Keys
Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places.
Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town.
Make Your Escape to Florida Keys
The results are in, and Florida Keys 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Florida Keys! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Florida Keys today and settle down in the lap of luxury tomorrow.
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Florida Keys Hotels by Star Rating
Hotels near Popular Florida Keys Attractions
- Duval Street
- Mallory Square
- John Pennekamp Coral Reef State Park
- Smathers Beach
- Sombrero Beach
- Southernmost Point
- Fort Zachary Taylor Historic State Park
- South Beach
- Jimmy Johnson's Big Chill
- Clarence S. Higgs Memorial Beach Park
- Seven Mile Bridge
- Biscayne National Park
- Baker's Cay Resort Beach
- Stock Island Yacht Club & Marina
More Hotel Options in Florida Keys
- Beach Hotel (236)
- Boutique Hotels (34)
- Business Hotels (87)
- Cheap Hotels (92)
- Family Hotels (208)
- Golf Hotels (121)
- Green Hotels (8)
- Historic Hotels (123)
- Honeymoon Resorts and Hotels (32)
- Hotel Wedding Venues (98)
- Hotels & Resorts for Couples (267)
- Hotels with Balconies (200)
- Hotels with Bar (164)
- Hotels with Childcare (13)
- Hotels with Early Check-in (7)
- Hotels with Free Airport Shuttle (8)
- Hotels with Free Breakfast (97)
- Hotels with Free Parking (187)
- Hotels with Hot Tubs (113)
- Hotels with Kitchenettes (60)
- Hotels with Tennis Courts (56)
- Hotels with Wifi (221)
- Hotels with a Pool (246)
- Hotels with smoking rooms (55)
- Lake Hotels (29)
- Luxury Hotels (120)
- Oceanfront Hotels (80)
- Pet-friendly Hotels (73)
- Romantic Hotels (169)
- Shopping Hotels (157)
- Ski Hotels (12)
- Spa Hotels (99)
More Accommodation Types in Florida Keys
- Vacation Homes in Florida Keys (748)
- Condo Rentals in Florida Keys (150)
- Villas in Florida Keys (60)
- Apartments in Florida Keys (32)
- Cottages in Florida Keys (31)
- Resorts in Florida Keys (14)
- RV Parks in Florida Keys (11)
- Houseboats in Florida Keys (9)
- Motels in Florida Keys (9)
- Aparthotels in Florida Keys (5)
- Cabin Rentals in Florida Keys (4)
- Guest Houses in Florida Keys (4)
- Lodges in Florida Keys (2)
- B&B in Florida Keys (1)
Explore more hotels
- Coconut Cay Resort & Marina
- Reefhouse Resort & Marina
- Fairfield Inn & Suites by Marriott Marathon Florida Keys
- Rock Reef Resort
- Amara Cay Resort
- Aqua Lodge Rentals At Coconut Cay
- Islander Resort
- Kingsail Resort
- Holiday Inn Key Largo, an IHG Hotel
- Waterside Suites & Marina
- Courtyard by Marriott Faro Blanco Resort
- Creekside Inn Islamorada
- The Pelican Key Largo Cottages
- Banana Bay Resort & Marina
- La Siesta Resort & Villas
- Rainbow Bend Resort
- Hampton Inn Key Largo Manatee Bay
- Tranquility Bay Beachfront Hotel and Resort
- Drift Hotel
- Key Largo Inn